Ontology highlight
ABSTRACT:
SUBMITTER: Gao SS
PROVIDER: S-EPMC6309916 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20180524 22
Duclauxins are dimeric and heptacyclic fungal polyketides with notable bioactivities. We characterized the cascade of redox transformations in the biosynthetic pathway of duclauxin from Talaromyces stipitatus. The redox reaction sequence is initiated by a cupin family dioxygenase DuxM that performs an oxidative cleavage of the peri-fused tricyclic phenalenone and affords a transient hemiketal-oxaphenalenone intermediate. Additional redox enzymes then morph the oxaphenoalenone into either an anhy ...[more]