Integrative Molecular Characterization of Malignant Pleural Mesothelioma.
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ABSTRACT:
SUBMITTER: Hmeljak J
PROVIDER: S-EPMC6310008 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Integrative Molecular Characterization of Malignant Pleural Mesothelioma.
Hmeljak Julija J Sanchez-Vega Francisco F Hoadley Katherine A KA Shih Juliann J Stewart Chip C Heiman David D Tarpey Patrick P Danilova Ludmila L Drill Esther E Gibb Ewan A EA Bowlby Reanne R Kanchi Rupa R Osmanbeyoglu Hatice U HU Sekido Yoshitaka Y Takeshita Jumpei J Newton Yulia Y Graim Kiley K Gupta Manaswi M Gay Carl M CM Diao Lixia L Gibbs David L DL Thorsson Vesteinn V Iype Lisa L Kantheti Havish H Severson David T DT Ravegnini Gloria G Desmeules Patrice P Jungbluth Achim A AA Travis William D WD Dacic Sanja S Chirieac Lucian R LR Galateau-Sallé Françoise F Fujimoto Junya J Husain Aliya N AN Silveira Henrique C HC Rusch Valerie W VW Rintoul Robert C RC Pass Harvey H Kindler Hedy H Zauderer Marjorie G MG Kwiatkowski David J DJ Bueno Raphael R Tsao Anne S AS Creaney Jenette J Lichtenberg Tara T Leraas Kristen K Bowen Jay J Felau Ina I Zenklusen Jean Claude JC Akbani Rehan R Cherniack Andrew D AD Byers Lauren A LA Noble Michael S MS Fletcher Jonathan A JA Robertson A Gordon AG Shen Ronglai R Aburatani Hiroyuki H Robinson Bruce W BW Campbell Peter P Ladanyi Marc M
Cancer discovery 20181015 12
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of <i>BAP1</i> alterations to date. We identified histology-independent molecular prognostic subsets, and defined a novel genomic subtype with <i>TP53</i> and <i>SETDB1</i> mutations and extensive loss of heterozygosity. We also report strong expression of the immune-checkp ...[more]
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