Dataset Information

Aggressiveness of solid pseudopapillary neoplasm of the pancreas: A literature review and meta-analysis.

ABSTRACT:

Background

Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare tumors considered to be benign although 10% to 15% of SPNs have been reported to be aggressive. Due to its rarity, there have only been a few cases reported regarding the clinical course of patients with aggressive SPNs. The goal of this study is to describe the clinical course of patients diagnosed with aggressive SPNs.

Methods

A PubMed search was done looking for articles describing the clinical course of patients diagnosed with SPN that locally invaded, recurred, or metastasized. Institutional experience was also added to the pooled data. Patient information was extracted from the articles. Survival and recurrence curves were plotted and factors associated with survival and recurrences were analyzed.

Results

A total of 59 patients were identified to have aggressive SPN. Seven patients were males and 52 were females and the mean age was 37.44?±?2.21 years. Systemic metastasis constituted 81.4% while recurrence and deep tissue invasion were found in 11.9% and 6.8% of the patients, respectively. Disease-free survival was 45?±?6.28 months and disease-specific survival was 152.67?±?12.8 months. In survival analysis, age, gender, tumor size, tumor location, combined resection, type of recurrence, and stage IV on diagnosis were not significant factors in predicting survival. However, an unresectable tumor (hazards ratio [HR]?=?4.871, 95% confidence interval [CI] 1.480-16.03, P?=?.009), and metastasis within 36 months (HR?=?6.399, 95% CI: 1.390-29.452, P?=?.017) were identified as independent variables in predicting survival.

Conclusion

SPNs of the pancreas carry a favorable course. Despite having aggressive properties, patients can still survive for more than 10 years as long as the tumor can be resected completely.

SUBMITTER: Hao EIU

PROVIDER: S-EPMC6310540 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Publications

Aggressiveness of solid pseudopapillary neoplasm of the pancreas: A literature review and meta-analysis.

Hao Emmanuel Ii Uy EIU Hwang Ho Kyung HK Yoon Dong-Sub DS Lee Woo Jung WJ Kang Chang Moo CM

Medicine 20181201 49

<h4>Background</h4>Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare tumors considered to be benign although 10% to 15% of SPNs have been reported to be aggressive. Due to its rarity, there have only been a few cases reported regarding the clinical course of patients with aggressive SPNs. The goal of this study is to describe the clinical course of patients diagnosed with aggressive SPNs.<h4>Methods</h4>A PubMed search was done looking for articles describing the clinical course of ...[more]

PMID: 30544374

Similar Datasets

Project description:ObjectiveSolid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor. This study aims to examine the clinicopathological features and surgical treatments of SPN and compare the clinical behavior and prognosis between men and women with SPN.MethodsWe collected the population data of patients with SPN diagnosed between 2004 and 2017 from the SEER database. The Kaplan-Meier method was used to analyze overall survival (OS) and disease-specific survival (DSS), and log-rank tests were used to evaluate the differences between subgroups. Univariate and multivariate Cox regression analyses were performed to screen out prognostic risk factors of SPN.ResultsA total of 378 patients with SPN were included, with 246 (65.1%) female patients. 1-, 3-, and 5-year overall survival rates were 98.9%, 95.7%, and 93.7%, respectively. Survival analysis revealed that regardless of stage, patients with SPN who underwent surgical interventions still had a significantly better prognosis than those without surgical interventions (P < .001). The patients with lymphatic dissection had a significantly better prognosis than those without lymphatic dissection (P < .001). Moreover, compared with female patients, male patients had significantly poorer OS and DSS (P < .001). Female SPN showed a bimodal age-frequency distribution with early-onset incidence at 28 years and late-onset peak incidence at 62 years, while male SPN presented a unimodal distribution with peak incidence at approximately age 64 years. In female patients, the tumor size in premenopausal females (<65 years old) was significantly larger than that in postmenopausal females (≥65 years old) (P < .001). Clinicopathological characteristic profiles were different not only between male SPN and premenopausal female SPN but also between premenopausal and postmenopausal female SPN.ConclusionSPN presents indolent behavior and predominantly occurs in young women. Regardless of stage, surgical intervention is recommended. Moreover, our study is the first large enough study to demonstrate sex-related discrepancies in SPN. Thus, different treatment strategies should be designed for patients of different sexes at different ages and hormone therapy is a promising approach for SPN.

Dataset Information

Aggressiveness of solid pseudopapillary neoplasm of the pancreas: A literature review and meta-analysis.

Background

Methods

Results

Conclusion

Publications

Aggressiveness of solid pseudopapillary neoplasm of the pancreas: A literature review and meta-analysis.

Similar Datasets

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