Ontology highlight
ABSTRACT:
SUBMITTER: Juan-Colas J
PROVIDER: S-EPMC6310807 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Juan-Colás José J Hitchcock Ian S IS Coles Mark M Johnson Steven S Krauss Thomas F TF
Proceedings of the National Academy of Sciences of the United States of America 20181210 52
Cell communication is primarily regulated by secreted proteins, whose inhomogeneous secretion often indicates physiological disorder. Parallel monitoring of innate protein-secretion kinetics from individual cells is thus crucial to unravel systemic malfunctions. Here, we report a label-free, high-throughput method for parallel, in vitro, and real-time analysis of specific single-cell signaling using hyperspectral photonic crystal resonant technology. Heterogeneity in physiological thrombopoietin ...[more]