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Piloting the membranolytic activities of peptides with a self-organizing map.

ABSTRACT: Antimicrobial peptides (AMPs) show remarkable selectivity toward lipid membranes and possess promising antibiotic potential. Their modes of action are diverse and not fully understood, and innovative peptide design strategies are needed to generate AMPs with improved properties. We present a de novo peptide design approach that resulted in new AMPs possessing low-nanomolar membranolytic activities. Thermal analysis revealed an entropy-driven mechanism of action. The study demonstrates sustained potential of advanced computational methods for designing peptides with the desired activity.

SUBMITTER: Lin YC

PROVIDER: S-EPMC6311381 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Piloting the membranolytic activities of peptides with a self-organizing map.

Lin Yen-Chu YC Hiss Jan A JA Schneider Petra P Thelesklaf Peter P Lim Yi Fan YF Pillong Max M Koehler Fabian M FM Dittrich Petra S PS Halin Cornelia C Wessler Silja S Schneider Gisbert G

Chembiochem : a European journal of chemical biology 20140909 15

Antimicrobial peptides (AMPs) show remarkable selectivity toward lipid membranes and possess promising antibiotic potential. Their modes of action are diverse and not fully understood, and innovative peptide design strategies are needed to generate AMPs with improved properties. We present a de novo peptide design approach that resulted in new AMPs possessing low-nanomolar membranolytic activities. Thermal analysis revealed an entropy-driven mechanism of action. The study demonstrates sustained ...[more]

PMID: 25204788

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