Ontology highlight
ABSTRACT:
SUBMITTER: Jarrad AM
PROVIDER: S-EPMC6311682 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Jarrad Angie M AM Ang Chee Wei CW Debnath Anjan A Hahn Hye Jee HJ Woods Kyra K Tan Lendl L Sykes Melissa L ML Jones Amy J AJ Pelingon Ruby R Butler Mark S MS Avery Vicky M VM West Nicholas P NP Karoli Tomislav T Blaskovich Mark A T MAT Cooper Matthew A MA
Journal of medicinal chemistry 20181211 24
Tuberculosis and parasitic diseases, such as giardiasis, amebiasis, leishmaniasis, and trypanosomiasis, all urgently require improved treatment options. Recently, it has been shown that antitubercular bicyclic nitroimidazoles such as pretomanid and delamanid have potential as repurposed therapeutics for the treatment of visceral leishmaniasis. Here, we show that pretomanid also possesses potent activity against Giardia lamblia and Entamoeba histolytica, thus expanding the therapeutic potential o ...[more]