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Common Variants in PLD3 and Correlation to Amyloid-Related Phenotypes in Alzheimer's Disease.

ABSTRACT: The phospholipase D3 (PLD3) gene has shown association with Alzheimer's disease (AD). However, the role of PLD3 common variants in amyloid-? (A?) pathology remains unclear. We examined the association of thirteen common single nucleotide polymorphisms (SNPs) with cerebrospinal fluid (CSF) A?(1- 42) levels and florbetapir retention on florbetapir 18F amyloid positron emission tomography (AV45-PET) in a large population. We found that one SNP (rs11667768) was significantly associated with CSF A?(1- 42) levels in the normal cognition group. We did not observe an association of any SNP with florbetapir retention. Our study predicted the potential role of PLD3 variants in A? pathology.

SUBMITTER: Wang C

PROVIDER: S-EPMC6312181 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Common Variants in PLD3 and Correlation to Amyloid-Related Phenotypes in Alzheimer's Disease.

Wang Chong C Tan Lan L Wang Hui-Fu HF Yu Wan-Jiang WJ Liu Ying Y Jiang Teng T Tan Meng-Shan MS Hao Xiao-Ke XK Zhang Dao-Qiang DQ Yu Jin-Tai JT

Journal of Alzheimer's disease : JAD 20150101 2

The phospholipase D3 (PLD3) gene has shown association with Alzheimer's disease (AD). However, the role of PLD3 common variants in amyloid-β (Aβ) pathology remains unclear. We examined the association of thirteen common single nucleotide polymorphisms (SNPs) with cerebrospinal fluid (CSF) Aβ(1- 42) levels and florbetapir retention on florbetapir 18F amyloid positron emission tomography (AV45-PET) in a large population. We found that one SNP (rs11667768) was significantly associated with CSF Aβ(1 ...[more]

PMID: 26402410

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