Ontology highlight
ABSTRACT:
SUBMITTER: Lyu X
PROVIDER: S-EPMC6312352 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Lyu Xiaoming X Wang Jianguo J Guo Xia X Wu Gongfa G Jiao Yang Y Faleti Oluwasijibomi Damola OD Liu Pengfei P Liu Tielian T Long Yufei Y Chong Tuotuo T Yang Xu X Huang Jing J He Mingliang M Tsang Chi Man CM Tsao Sai Wah SW Wang Qian Q Jiang Qiang Q Li Xin X
PLoS pathogens 20181217 12
Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Here, we reported that one of the key miRNAs encoded by EBV, EBV-miR-Bart1-5P, can significantly promote nasopharyngeal carcinoma (NPC) cell glycolysis and induces angiogenesis in vitro and in vivo ...[more]