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EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma.


ABSTRACT: Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Here, we reported that one of the key miRNAs encoded by EBV, EBV-miR-Bart1-5P, can significantly promote nasopharyngeal carcinoma (NPC) cell glycolysis and induces angiogenesis in vitro and in vivo. Mechanistically, EBV-miR-Bart1-5P directly targets the ?1 catalytic subunit of AMP-activated protein kinase (AMPK?1) and consequently regulates the AMPK/mTOR/HIF1 pathway which impelled NPC cell anomalous aerobic glycolysis and angiogenesis, ultimately leads to uncontrolled growth of NPC. Our findings provide new insights into metabolism and angiogenesis of NPC and new opportunities for the development of targeted NPC therapy in the future.

SUBMITTER: Lyu X 

PROVIDER: S-EPMC6312352 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma.

Lyu Xiaoming X   Wang Jianguo J   Guo Xia X   Wu Gongfa G   Jiao Yang Y   Faleti Oluwasijibomi Damola OD   Liu Pengfei P   Liu Tielian T   Long Yufei Y   Chong Tuotuo T   Yang Xu X   Huang Jing J   He Mingliang M   Tsang Chi Man CM   Tsao Sai Wah SW   Wang Qian Q   Jiang Qiang Q   Li Xin X  

PLoS pathogens 20181217 12


Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Here, we reported that one of the key miRNAs encoded by EBV, EBV-miR-Bart1-5P, can significantly promote nasopharyngeal carcinoma (NPC) cell glycolysis and induces angiogenesis in vitro and in vivo  ...[more]

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2022-04-07 | GSE155475 | GEO