Ontology highlight
ABSTRACT:
SUBMITTER: Nair N
PROVIDER: S-EPMC6312383 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nair Nitya N Feng Ningguo N Blum Lisa K LK Sanyal Mrinmoy M Ding Siyuan S Jiang Baoming B Sen Adrish A Morton John M JM He Xiao-Song XS Robinson William H WH Greenberg Harry B HB
Science translational medicine 20170601 395
Human rotaviruses (RVs) are the leading cause of severe diarrhea in young children worldwide. The molecular mechanisms underlying the rapid induction of heterotypic protective immunity to RV, which provides the basis for the efficacy of licensed monovalent RV vaccines, have remained unknown for more than 30 years. We used RV-specific single cell-sorted intestinal B cells from human adults, barcode-based deep sequencing of antibody repertoires, monoclonal antibody expression, and serologic and fu ...[more]