Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success.
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ABSTRACT:
SUBMITTER: Desai A
PROVIDER: S-EPMC6312440 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success.
Desai Amar A Yan Yan Y Gerson Stanton L SL
Stem cells translational medicine 20181017 1
Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem cell characteristics of self-renewal, quiescence, differentiation, and the ability to recapitulate the parental tumor when transplanted into a host. CSCs are correlated with poor clinical outcome due to their contribution to chemotherapy resistance and metastasis. Multiple cell surface and enzymatic markers have been characterized to identify CSCs within a heterogeneous tumor, and here we summarize ongoing ...[more]
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