Sequential Combined Effect of Phages and Antibiotics on the Inactivation of Escherichia coli.

ABSTRACT: The emergence of antibiotic resistance in bacteria is a global concern. The use of bacteriophages (or phages) alone or combined with antibiotics is consolidating itself as an alternative approach to inactivate antibiotic-resistant bacteria. However, phage-resistant mutants have been considered as a major threat when phage treatment is employed. Escherichia coli is one of the main responsible pathogens for moderate and serious infections in hospital and community environments, being involved in the rapid evolution of fluoroquinolones and third-generation cephalosporin resistance. The aim of this study was to evaluate the effect of combined treatments of phages and antibiotics in the inactivation of E. coli. For this, ciprofloxacin at lethal and sublethal concentrations was added at differen

SUBMITTER: Lopes A 

PROVIDER: S-EPMC6313441 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature