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The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection.


ABSTRACT: The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNF?, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis.

SUBMITTER: Chang AY 

PROVIDER: S-EPMC6313749 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection.

Chang Aileen Y AY   Tritsch Sarah S   Reid St Patrick SP   Martins Karen K   Encinales Liliana L   Pacheco Nelly N   Amdur Richard L RL   Porras-Ramirez Alexandra A   Rico-Mendoza Alejandro A   Li Guangzhao G   Peng Jin J   Firestein Gary S GS   Simon Gary L GL   Bethony Jeff M JM  

Diseases (Basel, Switzerland) 20181020 4


The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (<i>n</i> = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (<i>n</i> = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was corr  ...[more]

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