Unknown

Dataset Information

0

The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection.


ABSTRACT: The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNF?, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis.

SUBMITTER: Chang AY 

PROVIDER: S-EPMC6313749 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection.

Chang Aileen Y AY   Tritsch Sarah S   Reid St Patrick SP   Martins Karen K   Encinales Liliana L   Pacheco Nelly N   Amdur Richard L RL   Porras-Ramirez Alexandra A   Rico-Mendoza Alejandro A   Li Guangzhao G   Peng Jin J   Firestein Gary S GS   Simon Gary L GL   Bethony Jeff M JM  

Diseases (Basel, Switzerland) 20181020 4


The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (<i>n</i> = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (<i>n</i> = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was corr  ...[more]

Similar Datasets

| S-EPMC7885242 | biostudies-literature
| S-EPMC5927412 | biostudies-literature
| S-EPMC8127625 | biostudies-literature
| S-EPMC6167463 | biostudies-literature
| S-EPMC8470089 | biostudies-literature
| S-EPMC7802259 | biostudies-literature
| S-EPMC4054367 | biostudies-literature
| S-EPMC8254284 | biostudies-literature
| S-EPMC8894401 | biostudies-literature
2014-04-23 | E-GEOD-56965 | biostudies-arrayexpress