DNA Damage Response in Prostate Cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Schiewer MJ
PROVIDER: S-EPMC6314076 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
DNA Damage Response in Prostate Cancer.
Schiewer Matthew J MJ Knudsen Karen E KE
Cold Spring Harbor perspectives in medicine 20190102 1
Prostatic adenocarcinoma (PCa) remains a significant health concern. Although localized PCa can be effectively treated, disseminated disease remains uniformly fatal. PCa is reliant on androgen receptor (AR); as such, first-line therapy for metastatic PCa entails suppression of AR signaling. Although initially effective, recurrent tumors reactivate AR function, leading to a lethal stage of disease termed castration-resistant PCa (CRPC). Recent findings implicate AR signaling in control of DNA rep ...[more]
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