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Molecular Composition of Vestibular Hair Bundles.

ABSTRACT: The vertebrate hair bundle, responsible for transduction of mechanical signals into receptor potentials in sensory hair cells, is an evolutionary masterpiece. Composed of actin-filled stereocilia of precisely regulated length, width, and number, the structure of the hair bundle is optimized for sensing auditory and vestibular stimuli. Recent developments in identifying the lipids and proteins constituting the hair bundle, obtained through genetics, biochemistry, and imaging, now permit a description of the consensus composition of vestibular bundles of mouse, rat, and chick.

SUBMITTER: Krey JF 

PROVIDER: S-EPMC6314077 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Molecular Composition of Vestibular Hair Bundles.

Krey Jocelyn F JF   Barr-Gillespie Peter G PG  

Cold Spring Harbor perspectives in medicine 20190102 1

The vertebrate hair bundle, responsible for transduction of mechanical signals into receptor potentials in sensory hair cells, is an evolutionary masterpiece. Composed of actin-filled stereocilia of precisely regulated length, width, and number, the structure of the hair bundle is optimized for sensing auditory and vestibular stimuli. Recent developments in identifying the lipids and proteins constituting the hair bundle, obtained through genetics, biochemistry, and imaging, now permit a descrip  ...[more]