Ontology highlight
ABSTRACT:
SUBMITTER: Michael HT
PROVIDER: S-EPMC6314104 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Michael Helen T HT Graff-Cherry Cari C Chin Sung S Rauck Corinne C Habtemichael Amelework D AD Bunda Patricia P Smith Tunde T Campos Maria M MM Bharti Kapil K Arnheiter Heinz H Merlino Glenn G Day Chi-Ping CP
Investigative ophthalmology & visual science 20181201 15
<h4>Purpose</h4>Complete deficiency of microphthalmia transcription factor (MITF) in Mitfmi-vga9/mi-vga9 mice is associated with microphthalmia, retinal dysplasia, and albinism. We investigated the ability of dopachrome tautomerase (DCT) promoter-mediated inducible ectopic expression of Mitf-M to rescue these phenotypic abnormalities.<h4>Methods</h4>A new mouse line was created with doxycycline-inducible ectopic Mitf-M expression on an Mitf-deficient Mitfmi-vga9 background (DMV mouse). Adult DMV ...[more]