Thermodynamic constraints on the regulation of metabolic fluxes.
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ABSTRACT:
SUBMITTER: Dai Z
PROVIDER: S-EPMC6314121 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Thermodynamic constraints on the regulation of metabolic fluxes.
Dai Ziwei Z Locasale Jason W JW
The Journal of biological chemistry 20181025 51
Nutrition and metabolism are fundamental to cellular function. Metabolic activity (<i>i.e.</i> rates of flow, most commonly referred to as flux) is constrained by thermodynamics and regulated by the activity of enzymes. The general principles that relate biological and physical variables to metabolic control are incompletely understood. Using metabolic control analysis and computer simulations in several models of simplified metabolic pathways, we derive analytical expressions that define relati ...[more]
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