Giant tortoise genomes provide insights into longevity and age-related disease.
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ABSTRACT:
SUBMITTER: Quesada V
PROVIDER: S-EPMC6314442 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Giant tortoise genomes provide insights into longevity and age-related disease.
Quesada Víctor V Freitas-Rodríguez Sandra S Miller Joshua J Pérez-Silva José G JG Jiang Zi-Feng ZF Tapia Washington W Santiago-Fernández Olaya O Campos-Iglesias Diana D Kuderna Lukas F K LFK Quinzin Maud M Álvarez Miguel G MG Carrero Dido D Beheregaray Luciano B LB Gibbs James P JP Chiari Ylenia Y Glaberman Scott S Ciofi Claudio C Araujo-Voces Miguel M Mayoral Pablo P Arango Javier R JR Tamargo-Gómez Isaac I Roiz-Valle David D Pascual-Torner María M Evans Benjamin R BR Edwards Danielle L DL Garrick Ryan C RC Russello Michael A MA Poulakakis Nikos N Gaughran Stephen J SJ Rueda Danny O DO Bretones Gabriel G Marquès-Bonet Tomàs T White Kevin P KP Caccone Adalgisa A López-Otín Carlos C
Nature ecology & evolution 20181203 1
Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Here, we describe a global analysis of the genomes of Lonesome George-the iconic last member of Chelonoidis abingdonii-and the Aldabra giant tortoise (Aldabrachelys gigantea). Comparison of these genomes with those of related species, using both unsuper ...[more]
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