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Giant tortoise genomes provide insights into longevity and age-related disease.


ABSTRACT: Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Here, we describe a global analysis of the genomes of Lonesome George-the iconic last member of Chelonoidis abingdonii-and the Aldabra giant tortoise (Aldabrachelys gigantea). Comparison of these genomes with those of related species, using both unsupervised and supervised analyses, led us to detect lineage-specific variants affecting DNA repair genes, inflammatory mediators and genes related to cancer development. Our study also hints at specific evolutionary strategies linked to increased lifespan, and expands our understanding of the genomic determinants of ageing. These new genome sequences also provide important resources to help the efforts for restoration of giant tortoise populations.

SUBMITTER: Quesada V 

PROVIDER: S-EPMC6314442 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Giant tortoise genomes provide insights into longevity and age-related disease.

Quesada Víctor V   Freitas-Rodríguez Sandra S   Miller Joshua J   Pérez-Silva José G JG   Jiang Zi-Feng ZF   Tapia Washington W   Santiago-Fernández Olaya O   Campos-Iglesias Diana D   Kuderna Lukas F K LFK   Quinzin Maud M   Álvarez Miguel G MG   Carrero Dido D   Beheregaray Luciano B LB   Gibbs James P JP   Chiari Ylenia Y   Glaberman Scott S   Ciofi Claudio C   Araujo-Voces Miguel M   Mayoral Pablo P   Arango Javier R JR   Tamargo-Gómez Isaac I   Roiz-Valle David D   Pascual-Torner María M   Evans Benjamin R BR   Edwards Danielle L DL   Garrick Ryan C RC   Russello Michael A MA   Poulakakis Nikos N   Gaughran Stephen J SJ   Rueda Danny O DO   Bretones Gabriel G   Marquès-Bonet Tomàs T   White Kevin P KP   Caccone Adalgisa A   López-Otín Carlos C  

Nature ecology & evolution 20181203 1


Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Here, we describe a global analysis of the genomes of Lonesome George-the iconic last member of Chelonoidis abingdonii-and the Aldabra giant tortoise (Aldabrachelys gigantea). Comparison of these genomes with those of related species, using both unsuper  ...[more]

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