Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC6314529 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Chen Zhiyang Z Amro Elias Moris EM Becker Friedrich F Hölzer Martin M Rasa Seyed Mohammad Mahdi SMM Njeru Sospeter Ngoci SN Han Bing B Di Sanzo Simone S Chen Yulin Y Tang Duozhuang D Tao Si S Haenold Ronny R Groth Marco M Romanov Vasily S VS Kirkpatrick Joanna M JM Kraus Johann M JM Kestler Hans A HA Marz Manja M Ori Alessandro A Neri Francesco F Morita Yohei Y Rudolph K Lenhard KL
The Journal of experimental medicine 20181207 1
Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enhances their responsiveness to undergo differentiation and loss of self-renewal in response to inflammation. The study identifies <i>Rad21</i>/cohesin as a critical mediator of NF-κB signaling, which in ...[more]