Ontology highlight
ABSTRACT:
SUBMITTER: Jurgensen HJ
PROVIDER: S-EPMC6314555 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Jürgensen Henrik J HJ Nørregaard Kirstine S KS Sibree Megan M MM Santoni-Rugiu Eric E Madsen Daniel H DH Wassilew Katharina K Krustrup Dorrit D Garred Peter P Bugge Thomas H TH Engelholm Lars H LH Behrendt Niels N
The Journal of cell biology 20181026 1
Collectins such as mannose-binding lectin (MBL) and surfactant protein D (SP-D) become temporarily deposited in extravascular compartments after tissue injury and perform immune-stimulatory or inflammation-limiting functions. However, their turnover mechanisms, necessary to prevent excessive tissue damage, are virtually unknown. In this study, we show that fibroblasts in injured tissues undertake the clearance of collectins by using the endocytic collagen receptor uPARAP. In cellular assays, sev ...[more]