Ontology highlight
ABSTRACT:
SUBMITTER: Zebertavage L
PROVIDER: S-EPMC6314576 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zebertavage Lauren L Bambina Shelly S Shugart Jessica J Alice Alejandro A Zens Kyra D KD Lauer Peter P Hanson Bill B Gough Michael J MJ Crittenden Marka R MR Bahjat Keith S KS
PloS one 20190102 1
Dysregulated signaling via the epidermal growth factor receptor (EGFR)-family is believed to contribute to the progression of a diverse array of cancers. The most common variant of EGFR is EGFRvIII, which results from a consistent and tumor-specific in-frame deletion of exons 2-7 of the EGFR gene. This deletion generates a novel glycine at the junction and leads to constitutive ligand-independent activity. This junction forms a novel shared tumor neo-antigen with demonstrated immunogenicity in b ...[more]