Ontology highlight
ABSTRACT:
SUBMITTER: Arifuzzaman M
PROVIDER: S-EPMC6314830 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Arifuzzaman Mohammad M Mobley Yuvon R YR Choi Hae Woong HW Bist Pradeep P Salinas Cristina A CA Brown Zachary D ZD Chen Swaine L SL Staats Herman F HF Abraham Soman N SN
Science advances 20190102 1
Mast cells (MCs) are strategically distributed at barrier sites and prestore various immunocyte-recruiting cytokines, making them ideal targets for selective activation to treat peripheral infections. Here, we report that topical treatment with mastoparan, a peptide MC activator (MCA), enhances clearance of <i>Staphylococcus aureus</i> from infected mouse skins and accelerates healing of dermonecrotic lesions. Mastoparan functions by activating connective tissue MCs (CTMCs) via the MRGPRX2 (Mas- ...[more]