Ontology highlight
ABSTRACT:
SUBMITTER: Tzarum N
PROVIDER: S-EPMC6314831 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Tzarum Netanel N Giang Erick E Kong Leopold L He Linling L Prentoe Jannick J Augestad Elias E Hua Yuanzi Y Castillo Shaun S Lauer Georg M GM Bukh Jens J Zhu Jiang J Wilson Ian A IA Law Mansun M
Science advances 20190102 1
An effective vaccine to the antigenically diverse hepatitis C virus (HCV) must target conserved immune epitopes. Here, we investigate cross-neutralization of HCV genotypes by broadly neutralizing antibodies (bNAbs) encoded by the relatively abundant human gene family <i>V</i> <i><sub>H</sub></i> <i>1-69</i>. We have deciphered the molecular requirements for cross-neutralization by this unique class of human antibodies from crystal structures of HCV E2 in complex with bNAbs. An unusually high bin ...[more]