Ontology highlight
ABSTRACT:
SUBMITTER: Frost DC
PROVIDER: S-EPMC6314838 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Frost Dustin C DC Rust Clayton J CJ Robinson Renã A S RAS Li Lingjun L
Analytical chemistry 20180904 18
Multiplex isobaric tags have become valuable tools for high-throughput quantitative analysis of complex biological samples in discovery-based proteomics studies. Hybrid labeling strategies that pair stable isotope mass difference labeling with multiplex isobaric tag-based quantification further facilitate these studies by greatly increasing multiplexing capability. In this work, we present a cost-effective chemical labeling approach that couples duplex stable isotope dimethyl labeling with our c ...[more]