Ontology highlight
ABSTRACT:
SUBMITTER: Woodcock HV
PROVIDER: S-EPMC6315032 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Woodcock Hannah V HV Eley Jessica D JD Guillotin Delphine D Platé Manuela M Nanthakumar Carmel B CB Martufi Matteo M Peace Simon S Joberty Gerard G Poeckel Daniel D Good Robert B RB Taylor Adam R AR Zinn Nico N Redding Matthew M Forty Ellen J EJ Hynds Robert E RE Swanton Charles C Karsdal Morten M Maher Toby M TM Fisher Andrew A Bergamini Giovanna G Marshall Richard P RP Blanchard Andy D AD Mercer Paul F PF Chambers Rachel C RC
Nature communications 20190102 1
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR inhibition currently under clinical evaluation in IPF. Here we demonstrate that rapamycin-insensitive mTORC1 signaling via 4E-BP1 is a critical pathway for TGF-β<sub>1</sub> stimulated collagen synthesis in human lung fibroblasts, whereas canoni ...[more]