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First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal.

ABSTRACT: Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.

SUBMITTER: Caneiras C 

PROVIDER: S-EPMC6315367 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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First Description of Colistin and Tigecycline-Resistant <i>Acinetobacter baumannii</i> Producing KPC-3 Carbapenemase in Portugal.

Caneiras Cátia C   Calisto Filipa F   Jorge da Silva Gabriela G   Lito Luis L   Melo-Cristino José J   Duarte Aida A  

Antibiotics (Basel, Switzerland) 20181106 4

Herein, we describe a case report of carbapenem-resistant <i>Acinetobacter baumannii</i> and <i>Klebsiella pneumoniae</i> isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes <i>bla</i><sub>KPC-3</sub>, <i>bla</i><sub>TEM-1</sub> and <i>bla</i><sub>SHV-1</sub> in  ...[more]

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