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Cardiometabolic Health in Relation to Lifestyle and Body Weight Changes 3?8 Years Earlier.

ABSTRACT: The degree to which individuals change their lifestyle in response to interventions differs and this variation could affect cardiometabolic health. We examined if changes in dietary intake, physical activity and weight of obese infertile women during the first six months of the LIFEstyle trial were associated with cardiometabolic health 3?8 years later (N = 50?78). Lifestyle was assessed using questionnaires and weight was measured at baseline, 3 and 6 months after randomization. BMI, blood pressure, body composition, pulse wave velocity, glycemic parameters and lipid profile were assessed 3?8 years after randomization. Decreases in savory and sweet snack intake were associated with lower HOMA-IR 3?8 years later, but these associations disappeared after adjustment for current lifestyle. No other associations between changes in lifestyle or body weight during the first six months after randomization with cardiovascular health 3?8 years later were observed. In conclusion, reductions in snack intake were associated with reduced insulin resistance 3?8 years later, but adjustment for current lifestyle reduced these associations. This indicates that changing lifestyle is an important first step, but maintaining this change is needed for improving cardiometabolic health in the long-term.

SUBMITTER: Van Elten TM

PROVIDER: S-EPMC6315733 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Cardiometabolic Health in Relation to Lifestyle and Body Weight Changes 3⁻8 Years Earlier.

Van Elten Tessa M TM Van Poppel Mireille N M MNM Gemke Reinoud J B J RJBJ Groen Henk H Hoek Annemieke A Mol Ben W BW Roseboom Tessa J TJ

Nutrients 20181210 12

The degree to which individuals change their lifestyle in response to interventions differs and this variation could affect cardiometabolic health. We examined if changes in dietary intake, physical activity and weight of obese infertile women during the first six months of the LIFEstyle trial were associated with cardiometabolic health 3⁻8 years later (<i>N</i> = 50⁻78). Lifestyle was assessed using questionnaires and weight was measured at baseline, 3 and 6 months after randomization. BMI, blo ...[more]

PMID: 30544716

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Project description:Recent evidence suggests that resistance training (RT) may reduce metabolic and cardiovascular disease risk. We investigated whether overweight/class I obese individuals by BMI classification with high strength fitness exhibit cardiovascular/metabolic phenotypes similar to those overweight/obese and untrained or those normal-weight with high strength fitness.A total of 90 young males were categorized into three groups: overweight untrained (OU, n = 30, BMI > 27 kg·m?²), overweight trained (OT, n = 30, BMI > 27 kg·m?², RT ? 4 d·wk?¹), and normal-weight trained (NT, n = 30, BMI < 25 kg·m?², RT ? 4 d·wk?¹). Participants were assessed for strength, body composition, central/peripheral blood pressures, arterial stiffness, and markers of cardiovascular and metabolic health.Body weight was similar in OT and OU and greater than NT (P < 0.00001), and fat mass was different in all groups (P < 0.001). Compared to OU, NT and OT groups exhibited higher relative strength (NT = 46.7%, OT = 44.4%, P < 0.00001), subendocardial viability ratio (NT = 21.0%, P < 0.001; OT = 17.0%, P < 0.01), and lower brachial/central blood pressures (NT P < 0.001; OT P ? 0.05); augmentation index and pulse-wave velocity were lower only in OT (P < 0.05). Total cholesterol, low-density lipoprotein (NT P < 0.01, OT P < 0.05), triglycerides (NT = -50.4%, OT = -41.8%, P < 0.001), oxidized LDL (NT = -39.8%, OT = -31.8%, P < 0.001), and CRP (NT = -63.7%, OT = -67.4%, P < 0.01) levels were lower and high-density lipoprotein (NT = 26.9%, OT = 21.4%, P < 0.001) levels were higher in NT and OT compared to OU. NT and OT also exhibited lower amylin (NT = -55.8%, OT = -40.8%) and leptin (NT = -84.6%, OT = -59.4%) and higher adiponectin (NT = 87.5%, P < 0.001; OT = 78.1%, P < 0.01) and sex hormone-binding globulin (NT = 124.4%, OT = 92.3%, P < 0.001). Despite greater total and trunk fat in OT compared with NT, other than glucose and insulin, which were lower in NT than in both OT and OU (OT P < 0.01, OU P < 0.001), OT did not exhibit any impaired biomarker/phenotype compared to NT.These findings provide evidence that overweight/class I obese individuals with high strength fitness exhibit metabolic/cardiovascular risk profiles similar to normal-weight, fit individuals rather than overweight/class I obese unfit individuals. Strength training may be important to metabolic and cardiovascular health.

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Cardiometabolic Health in Relation to Lifestyle and Body Weight Changes 3?8 Years Earlier.

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Cardiometabolic Health in Relation to Lifestyle and Body Weight Changes 3⁻8 Years Earlier.

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