Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC6316044 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Zhang Lizhou L Ji Wei W Lyu Shuang S Qiao Luhua L Luo Guangxiang G
Viruses 20181209 12
Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as an important human viral pathogen, causing congenital malformation including microcephaly among infants born to mothers infected with the virus during pregnancy. Phylogenetic analysis suggested that ZIKV can be classified into African and Asian lineages. In this study, we have developed a stable plasmid-based reverse genetic system for robust production of both ZIKV prototype African-lineage MR766 and clinical Asian-lineage FSS ...[more]