Dataset Information

Deciphering the Role of the Non-Coding Genome in Regulating Gene-Diet Interactions.

ABSTRACT: Protein encoding genes constitute a small fraction of mammalian genomes. In addition to the protein coding genes, there are other functional units within the genome that are transcribed, but not translated into protein, the so called non-coding RNAs. There are many types of non-coding RNAs that have been identified and shown to have important roles in regulating gene expression either at the transcriptional or post-transcriptional level. A number of recent studies have highlighted that dietary manipulation in mammals can influence the expression or function of a number of classes of non-coding RNAs that contribute to the protein translation machinery. The identification of protein translation as a common target for nutritional regulation underscores the need to investigate how this may mechanistically contribute to phenotypes and diseases that are modified by nutritional intervention. Finally, we describe the state of the art and the application of emerging '-omics' technologies to address the regulation of protein translation in response to diet.

SUBMITTER: Law PP

PROVIDER: S-EPMC6316136 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Deciphering the Role of the Non-Coding Genome in Regulating Gene-Diet Interactions.

Law Pui-Pik PP Holland Michelle L ML

Nutrients 20181127 12

Protein encoding genes constitute a small fraction of mammalian genomes. In addition to the protein coding genes, there are other functional units within the genome that are transcribed, but not translated into protein, the so called non-coding RNAs. There are many types of non-coding RNAs that have been identified and shown to have important roles in regulating gene expression either at the transcriptional or post-transcriptional level. A number of recent studies have highlighted that dietary m ...[more]

PMID: 30486341

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Dataset Information

Deciphering the Role of the Non-Coding Genome in Regulating Gene-Diet Interactions.

Publications

Deciphering the Role of the Non-Coding Genome in Regulating Gene-Diet Interactions.

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