Ontology highlight
ABSTRACT:
SUBMITTER: Yeung TL
PROVIDER: S-EPMC6316352 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cancers 20181122 12
Increased number of tumor-infiltrating CD8+ lymphocytes is associated with improved survival in patients with advanced stage high grade serous ovarian cancer (HGSOC) but the underlying molecular mechanism has not been thoroughly explored. Using transcriptome profiling of microdissected HGSOC tissue with high and low CD8+ lymphocyte count and subsequent validation studies, we demonstrated that significantly increased ISG15 (Interferon-stimulated gene 15) expression in HGSOC was associated with hi ...[more]