Finding the Right Way to Target EGFR in Glioblastomas; Lessons from Lung Adenocarcinomas.
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ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC6316468 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Finding the Right Way to Target EGFR in Glioblastomas; Lessons from Lung Adenocarcinomas.
Gao Ya Y Vallentgoed Wies R WR French Pim J PJ
Cancers 20181204 12
The <i>EGFR</i> gene is one of the most frequently mutated and/or amplified gene both in lung adenocarcinomas (LUAD) and in glioblastomas (GBMs). Although both tumor types depend on the mutation for growth, clinical benefit of EGFR tyrosine kinase inhibitors (TKIs) has only been observed in LUAD patients and, thus-far, not in GBM patients. Also in LUAD patients however, responses are restricted to specific <i>EGFR</i> mutations only and these 'TKI-sensitive' mutations hardly occur in GBMs. This ...[more]
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