Ontology highlight
ABSTRACT:
SUBMITTER: Weng C
PROVIDER: S-EPMC6317315 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Weng Chenchun C Kosalka Joanna J Berkyurek Ahmet C AC Stempor Przemyslaw P Feng Xuezhu X Mao Hui H Zeng Chenming C Li Wen-Jun WJ Yan Yong-Hong YH Dong Meng-Qiu MQ Morero Natalia Rosalía NR Zuliani Cecilia C Barabas Orsolya O Ahringer Julie J Guang Shouhong S Miska Eric A EA
Genes & development 20181219 1-2
Piwi-interacting RNAs (piRNAs) engage Piwi proteins to suppress transposons and nonself nucleic acids and maintain genome integrity and are essential for fertility in a variety of organisms. In <i>Caenorhabditis elegans</i>, most piRNA precursors are transcribed from two genomic clusters that contain thousands of individual piRNA transcription units. While a few genes have been shown to be required for piRNA biogenesis, the mechanism of piRNA transcription remains elusive. Here we used functiona ...[more]