Ontology highlight
ABSTRACT:
SUBMITTER: Seibert SR
PROVIDER: S-EPMC6317347 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Seibert Stephan R SR Schladt David P DP Wu Baolin B Guan Weihua W Dorr Casey C Remmel Rory P RP Matas Arthur J AJ Mannon Roslyn B RB Israni Ajay K AK Oetting William S WS Jacobson Pamala A PA
Clinical transplantation 20181031 12
<h4>Background</h4>Suboptimal immunosuppression after kidney transplantation contributes to toxicity and loss of efficacy. Little is known regarding the impact of intra-patient variability of tacrolimus (TAC) doses and troughs in the early post-transplant period or the influence of genetic variants on variability.<h4>Methods</h4>Coefficients of variation (CV) of TAC troughs and doses of 1226 European American (EA) and 246 African American (AA) adult recipients enrolled in DeKAF Genomics were com ...[more]