Ontology highlight
ABSTRACT:
SUBMITTER: Diacou R
PROVIDER: S-EPMC6317371 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Diacou Raven R Zhao Yilin Y Zheng Deyou D Cvekl Ales A Liu Wei W
Cell reports 20181101 9
Gene regulation of multipotent neuroretinal progenitors is partially understood. Through characterizing Six3 and Six6 double knockout retinas (DKOs), we demonstrate Six3 and Six6 are jointly required for the maintenance of multipotent neuroretinal progenitors. Phenotypes in DKOs were not found in either Six3 nulls or Six6 nulls. At the far periphery, ciliary margin (CM) markers Otx1 and Cdon together with Wnt3a and Fzd1 were ectopically upregulated, whereas neuroretinal progenitor markers Sox2, ...[more]