Ontology highlight
ABSTRACT:
SUBMITTER: Zhang HE
PROVIDER: S-EPMC6317473 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zhang Hui Emma HE Hamson Elizabeth J EJ Koczorowska Maria Magdalena MM Tholen Stefan S Chowdhury Sumaiya S Bailey Charles G CG Lay Angelina J AJ Twigg Stephen M SM Lee Quintin Q Roediger Ben B Biniossek Martin L ML O'Rourke Matthew B MB McCaughan Geoffrey W GW Keane Fiona M FM Schilling Oliver O Gorrell Mark D MD
Molecular & cellular proteomics : MCP 20180926 1
Fibroblast activation protein-alpha (FAP) is a cell-surface transmembrane-anchored dimeric protease. This unique, constitutively active serine protease has both dipeptidyl aminopeptidase and endopeptidase activities and can hydrolyze the post-proline bond. FAP expression is very low in adult organs but is upregulated by activated fibroblasts in sites of tissue remodeling, including fibrosis, atherosclerosis, arthritis and tumors. To identify the endogenous substrates of FAP, we immortalized prim ...[more]