Dataset Information

Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk.

ABSTRACT: : media-1vid110.1542/5799877373001PEDS-VA_2018-1076Video Abstract BACKGROUND AND OBJECTIVE: Marijuana is the most commonly used recreational drug among breastfeeding women. With legalization of marijuana in several US states and a 1990 study in which authors documented psychomotor deficits in infants breastfed by mothers using marijuana, there is a need for information on potential exposure to the breastfed infant. Our objective with this study was to quantify cannabinoids in human milk after maternal marijuana use. METHODS:Between 2014 and 2017, 50 breastfeeding women who reported marijuana use provided 54 breast milk samples to a research repository, Mommy's Milk. Concentrations of ?-9-tetrahydrocannabinol (?9-THC), 11-hydroxy-?-9-tetrahydrocannabinol, cannabidiol, and cannabinol were measured by using liquid chromatography mass spectrometry electrospray ionization. RESULTS:?9-THC was detectable in 34 (63%) of the 54 samples up to ?6 days after last reported use; the median concentration of ?9-THC was 9.47 ng/mL (range: 1.01-323.00). Five samples had detectable levels of 11-hydroxy-?-9-tetrahydrocannabinol (range: 1.33-12.80 ng/mL) or cannabidiol (range: 1.32-8.56 ng/mL). The sample with the highest concentration of cannabidiol (8.56 ng/mL) did not have measurable ?9-THC. Cannabinol was not detected in any samples. The number of hours since last use was a significant predictor of log ?9-THC concentrations (-0.03; 95% confidence interval [CI] -0.04 to -0.01; P = .005). Adjusted for time since last use, the number of daily uses and time from sample collection to analysis were also significant predictors of log ?9-THC concentrations (0.51; 95% CI 0.03 to 0.99; P = .039; 0.08; 95% CI 0.00 to 0.15; P = .038, respectively). CONCLUSIONS:?9-THC was measurable in a majority of breast milk samples up to ?6 days after maternal marijuana use.

SUBMITTER: Bertrand KA

PROVIDER: S-EPMC6317767 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk.

Bertrand Kerri A KA Hanan Nathan J NJ Honerkamp-Smith Gordon G Best Brookie M BM Chambers Christina D CD

Pediatrics 20180901 3

: media-1vid110.1542/5799877373001PEDS-VA_2018-1076<b>Video Abstract</b> BACKGROUND AND OBJECTIVE: Marijuana is the most commonly used recreational drug among breastfeeding women. With legalization of marijuana in several US states and a 1990 study in which authors documented psychomotor deficits in infants breastfed by mothers using marijuana, there is a need for information on potential exposure to the breastfed infant. Our objective with this study was to quantify cannabinoids in human milk a ...[more]

PMID: 30150212

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Dataset Information

Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk.

Publications

Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk.

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