Ontology highlight
ABSTRACT:
SUBMITTER: Ryu JK
PROVIDER: S-EPMC6317891 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ryu Jae Kyu JK Rafalski Victoria A VA Meyer-Franke Anke A Adams Ryan A RA Poda Suresh B SB Rios Coronado Pamela E PE Pedersen Lars Østergaard LØ Menon Veena V Baeten Kim M KM Sikorski Shoana L SL Bedard Catherine C Hanspers Kristina K Bardehle Sophia S Mendiola Andrew S AS Davalos Dimitrios D Machado Michael R MR Chan Justin P JP Plastira Ioanna I Petersen Mark A MA Pfaff Samuel J SJ Ang Kenny K KK Hallenbeck Kenneth K KK Syme Catriona C Hakozaki Hiroyuki H Ellisman Mark H MH Swanson Raymond A RA Zamvil Scott S SS Arkin Michelle R MR Zorn Stevin H SH Pico Alexander R AR Mucke Lennart L Freedman Stephen B SB Stavenhagen Jeffrey B JB Nelson Robert B RB Akassoglou Katerina K
Nature immunology 20181015 11
Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer's disease (AD). However, the mechanisms that link disruption of the blood-brain barrier (BBB) to neurodegeneration are poorly understood, and exploration of fibrin as a therapeutic target has been limited by its beneficial clotting functions. Here we report the generation of monoclonal antibody ...[more]