Piezo's membrane footprint and its contribution to mechanosensitivity.
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ABSTRACT:
SUBMITTER: Haselwandter CA
PROVIDER: S-EPMC6317911 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Piezo's membrane footprint and its contribution to mechanosensitivity.
Haselwandter Christoph A CA MacKinnon Roderick R
eLife 20181127
Piezo1 is an ion channel that gates open when mechanical force is applied to a cell membrane, thus allowing cells to detect and respond to mechanical stimulation. Molecular structures of Piezo1 reveal a large ion channel with an unusually curved shape. This study analyzes how such a curved ion channel interacts energetically with the cell membrane. Through membrane mechanical calculations, we show that Piezo1 deforms the membrane shape outside the perimeter of the channel into a curved 'membrane ...[more]
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