Ontology highlight
ABSTRACT:
SUBMITTER: Wang E
PROVIDER: S-EPMC6318000 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Wang Edina E Sorolla Anabel A Cunningham Paula T PT Bogdawa Heique M HM Beck Samuel S Golden Emily E Dewhurst Robert E RE Florez Laura L Cruickshank Mark N MN Hoffmann Katrin K Hopkins Richard M RM Kim Jonghwan J Woo Andrew J AJ Watt Paul M PM Blancafort Pilar P
Oncogene 20180803 1
Overexpression of MYC oncogene is highly prevalent in many malignancies such as aggressive triple-negative breast cancers (TNBCs) and it is associated with very poor outcome. Despite decades of research, attempts to effectively inhibit MYC, particularly with small molecules, still remain challenging due to the featureless nature of its protein structure. Herein, we describe the engineering of the dominant-negative MYC peptide (OmoMYC) linked to a functional penetrating 'Phylomer' peptide (FPPa) ...[more]