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Defect engineered bioactive transition metals dichalcogenides quantum dots.


ABSTRACT: Transition metal dichalcogenide (TMD) quantum dots (QDs) are fundamentally interesting because of the stronger quantum size effect with decreased lateral dimensions relative to their larger 2D nanosheet counterparts. However, the preparation of a wide range of TMD QDs is still a continual challenge. Here we demonstrate a bottom-up strategy utilizing TM oxides or chlorides and chalcogen precursors to synthesize a small library of TMD QDs (MoS2, WS2, RuS2, MoTe2, MoSe2, WSe2 and RuSe2). The reaction reaches equilibrium almost instantaneously (~10-20?s) with mild aqueous and room temperature conditions. Tunable defect engineering can be achieved within the same reactions by deviating the precursors' reaction stoichiometries from their fixed molecular stoichiometries. Using MoS2 QDs for proof-of-concept biomedical applications, we show that increasing sulfur defects enhanced oxidative stress generation, through the photodynamic effect, in cancer cells. This facile strategy will motivate future design of TMDs nanomaterials utilizing defect engineering for biomedical applications.

SUBMITTER: Ding X 

PROVIDER: S-EPMC6318297 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Defect engineered bioactive transition metals dichalcogenides quantum dots.

Ding Xianguang X   Peng Fei F   Zhou Jun J   Gong Wenbin W   Slaven Garaj G   Loh Kian Ping KP   Lim Chwee Teck CT   Leong David Tai DT  

Nature communications 20190103 1


Transition metal dichalcogenide (TMD) quantum dots (QDs) are fundamentally interesting because of the stronger quantum size effect with decreased lateral dimensions relative to their larger 2D nanosheet counterparts. However, the preparation of a wide range of TMD QDs is still a continual challenge. Here we demonstrate a bottom-up strategy utilizing TM oxides or chlorides and chalcogen precursors to synthesize a small library of TMD QDs (MoS<sub>2</sub>, WS<sub>2</sub>, RuS<sub>2</sub>, MoTe<sub  ...[more]

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