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ABSTRACT: Objective
To review the association between hypertension and frailty in observational studies.Design
A systematic review of the PubMed, Web of Science and Embase databases was performed. A meta-analysis was performed if at least three studies used the same definition of frailty and a dichotomous definition of hypertension.Setting, participants and measures
Studies providing information on the association between frailty and hypertension in adult persons, regardless of the study setting, study design or definition of hypertension and frailty were included.Results
Among the initial 964 articles identified, 27 were included in the review. Four longitudinal studies examined the incidence of frailty according to baseline hypertension status, providing conflicting results. Twenty-three studies assessed the cross-sectional association between frailty and hypertension: 13 of them reported a significantly higher prevalence of frailty in hypertensive participants and 10 found no significant association. The pooled prevalence of hypertension in frail individuals was 72% (95% CI 66% to 79%) and the pooled prevalence of frailty in individuals with hypertension was 14% (95% CI 12% to 17%). Five studies, including a total of 7656 participants, reported estimates for the association between frailty and hypertension (pooled OR 1.33; 95%?CI 0.94 to 1.89).Conclusions
Frailty is common in persons with hypertension. Given the possible influence of frailty on the risk-benefit ratio of treatment for hypertension and its high prevalence, it is important to assess the presence of this condition in persons with hypertension.Trial registration number
CRD42017058303.
SUBMITTER: Vetrano DL
PROVIDER: S-EPMC6318510 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Vetrano Davide L DL Palmer Katie M KM Galluzzo Lucia L Giampaoli Simona S Marengoni Alessandra A Bernabei Roberto R Onder Graziano G
BMJ open 20181228 12
<h4>Objective</h4>To review the association between hypertension and frailty in observational studies.<h4>Design</h4>A systematic review of the PubMed, Web of Science and Embase databases was performed. A meta-analysis was performed if at least three studies used the same definition of frailty and a dichotomous definition of hypertension.<h4>Setting, participants and measures</h4>Studies providing information on the association between frailty and hypertension in adult persons, regardless of the ...[more]