Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution.
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ABSTRACT:
SUBMITTER: Shain AH
PROVIDER: S-EPMC6319271 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution.
Shain A Hunter AH Joseph Nancy M NM Yu Richard R Benhamida Jamal J Liu Shanshan S Prow Tarl T Ruben Beth B North Jeffrey J Pincus Laura L Yeh Iwei I Judson Robert R Bastian Boris C BC
Cancer cell 20180701 1
We elucidated genomic and transcriptomic changes that accompany the evolution of melanoma from pre-malignant lesions by sequencing DNA and RNA from primary melanomas and their adjacent precursors, as well as matched primary tumors and regional metastases. In total, we analyzed 230 histopathologically distinct areas of melanocytic neoplasia from 82 patients. Somatic alterations sequentially induced mitogen-activated protein kinase (MAPK) pathway activation, upregulation of telomerase, modulation ...[more]
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