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Evaluation of pre-mir-34a rs72631823 single nucleotide polymorphism in triple negative breast cancer: A case-control study.

ABSTRACT: Aim:The purpose of this study is to evaluate the role of pre-miR34a rs72631823 as potential risk factor and/or prognostic marker in patients with triple negative breast cancer. Methods:114 samples of DNA from paraffin embedded breast normal tissues of patients with triple negative breast cancer and 124 samples of healthy controls were collected and analyzed for pre-miR34a rs72631823 polymorphism. Results:Pre-miR34a rs72631823 A allele was associated with increased TNBC risk both in univariate and multivariate analysis. The number of pre-miR34a rs72631823 AA subjects was very small and the association did not reach significance (p = 0.176, Fisher's exact test). The examined polymorphism was not associated with overall survival at the univariate or multivariate Cox regression analysis (adjusted HR = 1.60, 95%CI: 0.64-3.96 for miR34 rs72631823 GA/AA vs. GG). Conclusion:Our case-control study suggests that pre-miR34a rs72631823 A allele is associated with increased triple negative breast cancer risk.

SUBMITTER: Kalapanida D 

PROVIDER: S-EPMC6319339 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Evaluation of pre-mir-34a rs72631823 single nucleotide polymorphism in triple negative breast cancer: A case-control study.

Kalapanida Despoina D   Zagouri Flora F   Gazouli Maria M   Zografos Eleni E   Dimitrakakis Constantine C   Marinopoulos Spyridon S   Giannos Aris A   Sergentanis Theodoros N TN   Kastritis Efstathios E   Terpos Evangelos E   Dimopoulos Meletios-Athanasios MA  

Oncotarget 20181211 97

<h4>Aim</h4>The purpose of this study is to evaluate the role of pre-miR34a rs72631823 as potential risk factor and/or prognostic marker in patients with triple negative breast cancer.<h4>Methods</h4>114 samples of DNA from paraffin embedded breast normal tissues of patients with triple negative breast cancer and 124 samples of healthy controls were collected and analyzed for pre-miR34a rs72631823 polymorphism.<h4>Results</h4>Pre-miR34a rs72631823 A allele was associated with increased TNBC risk  ...[more]

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