Dataset Information

Serum high-density lipoprotein cholesterol is a protective predictor of executive function in older patients with diabetes mellitus.

ABSTRACT:

Aims/introduction

Older people with diabetes mellitus are at high risk for cognitive impairment or dementia. The clinical predictors for cognitive decline in older people with diabetes mellitus were elucidated.

Materials and methods

This was a secondary analysis of a vitamin B₁₂ intervention trial in older people with diabetes mellitus. A total of 271 non-demented individuals were followed up at 9-month intervals for 27 months. We explored the association between baseline clinical features with changes in cognitive measures (Clinical Dementia Rating scale, Neuropsychological Test Battery including executive function z-scores, psychomotor speed z-scores and memory z-scores).

Results

A total of 152 participants had normal cognition (Clinical Dementia Rating 0) and 119 had cognitive impairment (Clinical Dementia Rating 0.5) at baseline. After 27 months, 41 participants had cognitive decline, 36 of whom were cognitively normal at baseline. Multiple logistic regression showed no significant clinical predictor of global cognitive decline. Higher high-density lipoprotein cholesterol (HDL-C) was associated with better executive performance at month 27 (? = 0.359, P < 0.001). Multilevel modeling showed that the highest tertile of HDL-C was associated with better executive function z-scores than the lowest tertile of HDL-C at all time-points.

Conclusions

Among older people with diabetes mellitus, higher serum HDL-C was associated with better executive function.

SUBMITTER: Sun Y

PROVIDER: S-EPMC6319476 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Serum high-density lipoprotein cholesterol is a protective predictor of executive function in older patients with diabetes mellitus.

Sun Yue Y Lee Jenny J Ma Ronald C RC Kwok Timothy T

Journal of diabetes investigation 20180630 1

<h4>Aims/introduction</h4>Older people with diabetes mellitus are at high risk for cognitive impairment or dementia. The clinical predictors for cognitive decline in older people with diabetes mellitus were elucidated.<h4>Materials and methods</h4>This was a secondary analysis of a vitamin B<sub>12</sub> intervention trial in older people with diabetes mellitus. A total of 271 non-demented individuals were followed up at 9-month intervals for 27 months. We explored the association between baseli ...[more]

PMID: 29777621

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Project description:Background and objectiveKlotho is a protein that is closely related to human aging. Soluble Klotho (S-Klotho) is a circulating protein, and its level decreases in response to systemic inflammation. The relationship between the platelet/high-density lipoprotein cholesterol ratio (PHR), an emerging inflammatory index, and S-Klotho concentrations is still unclear. In addition, the mean platelet volume has been confirmed to have a significant negative association with S-Klotho concentrations, but the relationship between the platelet count (PC) and S-Klotho concentrations has not yet been reported.MethodsData from individuals who participated in the National Health and Nutrition Examination Survey (NHANES) during the five cycles from 2007 to 2016 were retrieved for analysis. Linear regression, two-piecewise linear regression, and restricted cubic spline (RCS) methods were used to analyze the associations of the PHR index and its components with S-Klotho concentrations. In addition, subgroup analysis and effect modification tests were conducted.ResultsA total of 11,123 participants (5463 men (48.17%)), with an average age of 56.2 years, were included. After full adjustment, the S-Klotho levels of participants in the highest quartile group of PHR (β: -51.19, 95% CI: -75.41 to -26.97, P < 0.001) and the highest quartile group of PC (β: -72.34, 95% CI: -93.32 to -51.37, P < 0.0001) were significantly lower than those in their respective lowest quartile groups, and a significant downward trend was presented among the four groups (P for trend < 0.05, respectively). However, high-density lipoprotein cholesterol (HDL-C) concentrations were not significantly associated with S-Klotho concentrations. RCS revealed that the PHR and PC were nonlinearly associated with S-Klotho concentrations; two-piecewise linear regression revealed that the inflection points were 175.269 and 152, respectively, and that these associations slightly weakened after the inflection point. According to the subgroup analysis, liver disease status enhanced the association between the PC and S-Klotho concentrations.ConclusionsBoth the PHR and PC were significantly negatively associated with S-Klotho concentrations, and these associations were nonlinear. There was no significant association between HDL-C and S-Klotho concentrations. Liver disease status enhances the negative association between the PC and S-Klotho concentrations, and the specific mechanism deserves further exploration.

Dataset Information

Serum high-density lipoprotein cholesterol is a protective predictor of executive function in older patients with diabetes mellitus.

Aims/introduction

Materials and methods

Results

Conclusions

Publications

Serum high-density lipoprotein cholesterol is a protective predictor of executive function in older patients with diabetes mellitus.

Similar Datasets

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