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ABSTRACT:
SUBMITTER: Bekker GJ
PROVIDER: S-EPMC6319760 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Bekker Gert-Jan GJ Ma Benson B Kamiya Narutoshi N
Protein science : a publication of the Protein Society 20181220 2
Single-domain antibodies (sdAbs) function like regular antibodies, however, consist of only one domain. Because of their low molecular weight, sdAbs have advantages with respect to production and delivery to their targets and for applications such as antibody drugs and biosensors. Thus, sdAbs with high thermal stability are required. In this work, we chose seven sdAbs, which have a wide range of melting temperature (T<sub>m</sub> ) values and known structures. We applied molecular dynamics (MD) ...[more]