Ontology highlight
ABSTRACT:
SUBMITTER: Parlea L
PROVIDER: S-EPMC6319925 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Methods (San Diego, Calif.) 20160426
Designing self-assembling RNA ring structures based on known 3D structural elements connected via linker helices is a challenging task due to the immense number of motif combinations, many of which do not lead to ring-closure. We describe an in silico solution to this design problem by combinatorial assembly of RNA 3-way junctions, bulges, and kissing loops, and tabulating the cases that lead to ring formation. The solutions found are made available in the form of a web-accessible Ring Catalog. ...[more]