Ontology highlight
ABSTRACT:
SUBMITTER: Mostaghel EA
PROVIDER: S-EPMC6320302 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Mostaghel Elahe A EA Zhang Ailin A Hernandez Susana S Marck Brett T BT Zhang Xiaotun X Tamae Daniel D Biehl Heather E HE Tretiakova Maria M Bartlett Jon J Burns John J Dumpit Ruth R Ang Lisa L Matsumoto Alvin M AM Penning Trevor M TM Balk Steven P SP Morrissey Colm C Corey Eva E True Lawrence D LD Nelson Peter S PS
Clinical cancer research : an official journal of the American Association for Cancer Research 20180904 1
<h4>Purpose</h4>Tumor androgens in castration-resistant prostate cancer (CRPC) reflect <i>de novo</i> intratumoral synthesis or adrenal androgens. We used C.B.-17 SCID mice in which we observed adrenal CYP17A activity to isolate the impact of adrenal steroids on CRPC tumors <i>in vivo</i>.<h4>Experimental design</h4>We evaluated tumor growth and androgens in LuCaP35CR and LuCaP96CR xenografts in response to adrenalectomy (ADX). We assessed protein expression of key steroidogenic enzymes in 185 C ...[more]