Ontology highlight
ABSTRACT:
SUBMITTER: Zidi B
PROVIDER: S-EPMC6320535 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zidi Bochra B Vincent-Fabert Christelle C Pouyet Laurent L Seillier Marion M Vandevelde Amelle A N'guessan Prudence P Poplineau Mathilde M Guittard Geoffrey G Mancini Stéphane J C SJC Duprez Estelle E Carrier Alice A
Proceedings of the National Academy of Sciences of the United States of America 20181217 1
Bone marrow (BM) produces all blood and immune cells deriving from hematopoietic stem cells (HSCs). The decrease of immune cell production during aging is one of the features of immunosenescence. The impact of redox dysregulation in BM aging is still poorly understood. Here we use TP53INP1-deficient (KO) mice endowed with chronic oxidative stress to assess the influence of aging-associated redox alterations in BM homeostasis. We show that TP53INP1 deletion has no impact on aging-related accumula ...[more]