Itaconic acid degradation in Aspergillus niger: the role of unexpected bioconversion pathways.

ABSTRACT:

Background

Itaconic acid (IA), a C5-dicarboxylic acid, has previously been identified as one of the top twelve biochemicals that can be produced by biotechnological means. IA is naturally produced by Aspergillus terreus, however, heterologous production in the related species Aspergillus niger has been proposed earlier. Remarkably, we observed that during high producing conditions and elevated titers A. niger detoxifies the extracellular medium of IA. In order to determine the genes responsible for this decline in IA titers a transcriptome analysis was performed.

Results

Transcriptome analysis has led to the identification of two novel and previously unknown IA bioconversion pathways in A. niger. One pathway is proposed to convert IA

SUBMITTER: Hossain AH 

PROVIDER: S-EPMC6320622 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature