Ontology highlight
ABSTRACT:
SUBMITTER: Yang GJ
PROVIDER: S-EPMC6320820 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Yang Guan-Jun GJ Lei Pui-Man PM Wong Suk-Yu SY Ma Dik-Lung DL Leung Chung-Hang CH
Molecules (Basel, Switzerland) 20181204 12
Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell proliferation, cell metastasis and invasiveness, and is associated with inferior prognosis. Pharmacological inhibition of LSD1 has been reported to significantly attenuate tumor progression in vitro and in vivo in a range of solid tumors and acute my ...[more]