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The MTNR1B rs10830963 Variant in Interaction with Pre-Pregnancy BMI is a Pharmacogenetic Marker for the Initiation of Antenatal Insulin Therapy in Gestational Diabetes Mellitus.


ABSTRACT: The rs10830963 variant of the Melatonin Receptor 1B (MTNR1B) gene is associated with the development of gestational diabetes mellitus (GDM). We hypothesized that carrying the rs10830963/G risk allele had effect on antenatal insulin therapy (AIT) initiation in GDM in a body mass index (BMI)-dependent manner. Design: In this post hoc analysis the MTNR1B rs10830963 genotype and the clinical data of 211 Caucasian GDM patients were assessed. As a first step, a pre-pregnancy BMI threshold was determined where the effect of MTNR1B rs10830963/G allele carrying on AIT initiation was the most significant using logistic regression. Maternal age adjusted real-life odds ratios (OR) values were calculated. The chi-square test was also used to calculate the p value and 10.000 bootstrap simulations were performed in each case to re-assess the statistical power and the OR. Carrying the MTNR1B rs10830963/G allele increased the odds of AIT initiation (OR = 5.2, p = 0.02 [?² test], statistical power = 0.53) in GDM patients with pre-pregnancy BMI ? 29 kg/m². The statistical power reached 0.77, when the pre-pregnancy BMI cutoff of 27 kg/m² was used and the genetic effect on AIT initiation was still significant, but only using the logistic regression model. Carrying the MTNR1B rs10830963/G risk allele-in interaction with pre-pregnancy BMI-is likely be considered as a candidate pharmacogenetic marker of antenatal insulin therapy initiation and should be further assessed in precision medicine trials in GDM.

SUBMITTER: Firneisz G 

PROVIDER: S-EPMC6321391 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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The <i>MTNR1B</i> rs10830963 Variant in Interaction with Pre-Pregnancy BMI is a Pharmacogenetic Marker for the Initiation of Antenatal Insulin Therapy in Gestational Diabetes Mellitus.

Firneisz Gábor G   Rosta Klara K   Al-Aissa Zahra Z   Hadarits Orsolya O   Harreiter Jürgen J   Nádasdi Ákos Á   Bancher-Todesca Dagmar D   Németh László L   Igaz Péter P   Rigó János J   Sziller István I   Kautzky-Willer Alexandra A   Somogyi Anikó A  

International journal of molecular sciences 20181123 12


The rs10830963 variant of the <i>Melatonin Receptor 1B</i> (<i>MTNR1B</i>) gene is associated with the development of gestational diabetes mellitus (GDM). We hypothesized that carrying the rs10830963/<i>G</i> risk allele had effect on antenatal insulin therapy (AIT) initiation in GDM in a body mass index (BMI)-dependent manner. <i>Design</i>: In this post hoc analysis the <i>MTNR1B</i> rs10830963 genotype and the clinical data of 211 Caucasian GDM patients were assessed. As a first step, a pre-p  ...[more]

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